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KMID : 0377619640060050571
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Korean Jungang Medical Journal
1964 Volume.6 No. 5 p.571 ~ p.580
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Studies on the Variations of Tuberculin Allergy
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Abstract
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Today, faith in ,the tuberculin test is again vacillating , as it becomes overwhelmingly evident that tubercle bacillus is not the only cause of tuberculin sensitivity in human beings. There has been increasing evidence that, some of the weak reactions to the standard first dose are generally harmless infection with numerous mycobacteria like atypical acid-fast bacilli. The author formulated the. hypothesis that the frequent variations of tuberculin allergy, especially in the weak reactors, may due to the reinfection of those atypical acid-fast bacilli other than tubercle bacilli. To test the hypothesis, experiments have been carried out to determine whe ther early reconversion will or will not occur after vaccinations of various atypical acid-fast bacilli were given to those who had become negative reactors after BCG vaccination, The results are as follows;
1. The vaccination of photochromogens, non-photochromogens, and scotochromogens to the reversals of BCG vaccination caused the early reconversion of tuberculin allergy at a markedly higher rates and with stronger reactions than the control group and the group vaccinated with mycobacterium smeginatis orphlei.
The rate of early reconversion revealed higher in the group those vaccinated with photochromogens or non-photochromogens than those vaccinated with scotochromogns,
3. Those vaccinated with BCG revealed higher rate in early reconversion than those vaccinated with photochromogens
4 Early reconversion of tuberculin allergy with the vaccinations of various atypical acid-fast bacilli revealed higher positive and stronger reactions in the group of
a. vaccinated within shorter time interval after BCG vacicnation,
b. those vaccinated previosly with BCG which contained a larger numbe bacilli,
c. those vaccinated repeatedly with BCG.
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